Research Article
Green Synthesis, Characterization and Biological Evaluation of Divalent Transition Metal Complexes of Substituted Aminopyrimidine Novel Schiff Base Ligand
Dhondiram Tukaram Sakhare*
Issue:
Volume 13, Issue 1, February 2025
Pages:
1-10
Received:
4 November 2024
Accepted:
22 December 2024
Published:
7 January 2025
DOI:
10.11648/j.sjc.20251301.11
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Abstract: The aminopyrimidines so obtained were converted into Schiff bases by treating with different substituted aldehydes, The study of novel heterocyclic Schiff base ligands 3-{[(4,6-dihydroxy pyrimidin-2-yl)Imino]methyl}Napthalen-2-ol or 2-(((2-hydroxynaphthalen-1-yl)methylene)amino)pyrimidine-4,6-diol derived from 2-amino-4, 6-dihydroxypyrimidine and 2-hydroxy-1-naphthaldehyde (L) were synthesized. These ligands have been used in the synthesis of Cr(II) complexes. The ligand coordinates to the metal ions in the ratio 2L: 1M, through the azomethine N and napthol O atoms, resulting in N2O2 chromophores around the central metal atom. The structures of synthesized compounds were confirmed by physical parameters and spectral studies. The synthesized compounds were characterized using FT-IR, 1H-NMR, UV-Vis techniques for the ligands, Thin layer chromatography (TLC) for all reactions, and molar conductivity and magnetic susceptibility measurements for the corresponding reactions. The general formula of the complexes is [Cr(L)2(H2O)2]. The complexes are paramagnetic in nature. Molar conductivity measurements showed that all complexes in (DMSO) are non electrolytes. Octahedral geometry of all complexes. The ligands are bidentate (L) due to the phenolic (OH) nitrogen and the azomethine nitrogen. The ligands and their complexes were examined for antifungal and antibacterial activity against Aspergillus niger, Penicillium chrysogenum, Fusarium moneriforme, and Aspergillus flavus, as well as Escherichia coli, Salmonella typhi, Staphylococcus aureus, and Bacillus subtilis. The results showed that the complexes have excellent antifungal and antibacterial effects.
Abstract: The aminopyrimidines so obtained were converted into Schiff bases by treating with different substituted aldehydes, The study of novel heterocyclic Schiff base ligands 3-{[(4,6-dihydroxy pyrimidin-2-yl)Imino]methyl}Napthalen-2-ol or 2-(((2-hydroxynaphthalen-1-yl)methylene)amino)pyrimidine-4,6-diol derived from 2-amino-4, 6-dihydroxypyrimidine and 2...
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